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High performance magnetic nanoparticle (PuriMag G beads)


2018/2/20 Viewers:



In pharmaceutical research, it is extremely important to perform isolate and identify the protein that is the target of a drug (compound) in vivo. However in the past, isolation and identification of the drug target protein were extremely difficult, and were a problem which required large amounts of time and effort. In order to overcome this problem, PuriMag Biotech has developed the new nanomagnetic particles "PuriMag-G beads" which are adapt to all automated systems. 

PuriMag-beads are approximately 200 nm in diameter that are composed of multiple ferrite particles coated with a special polymer called poly-GMA (glycidyl methacrylate). The PuriMag-beads that are manufactured using this original technology are used as materices for affinity purification and provide characteristics that are superior to conventional materices, allowing one-step purification of the drug target protein. The development of an automated screening system that magnetically separates and disperses the PuriMag-beads makes it possible to automate the affinity purification process, process multiple samples simultaneously, and shorten the time required.


Features
Extremely low non-specific binding:
poly-GMA (Glycidyl methacrylate) coated magnetic nanoparticles
Excellent recovery of target proteins:
200 nm particles have a large surface area and a high dispersibility
High stability in organic solvents:
various compounds can be immobilized on the beads

Various Magnetic Beads
PuriMag-beads can capture a variety of substances, including chemicals (drugs), proteins, and DNA. From the 16 types of PuriMag-beads, select the type with the optimal surface modification according to the functional group of the substance you want to bind. Because PuriMag-beads are resistant to various organic solvents, they are able to bind a variety of ligands. (Avoid using streptavidin beads or other protein-binding PuriMag-beads in organic solvents.) The beads with ligands immobilized can be used for affinity purification of the target biological substance.

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